Cystinosis awareness day

Cystinosis Awareness Day takes place annually on 7 May The first annual Cystinosis Awareness Day took place on 7 May 2018 and was sponsored by the Cystinosis Research Network. Cystinosis is a rare multisystem genetic disorder which causes abnormal accumulation of the amino acid cystine in organs and tissues of the body. The purpose of Cystinosis Awareness Day is to educate the public concerning this condition which most frequently affects the eyes and kidneys, but left untreated, it can eventually affect all tissues of the body. Early diagnosis and treatment are key to mitigating its affects.

Cystine is the oxidized dimer form of the amino acid cysteine and has the formula (SCH2CH(NH2)CO2H)2. It is a white solid that is slightly soluble in water. It serves two biological functions: a site of redox reactions and a mechanical linkage that allows proteins to retain their three-dimensional structure. It is common in many foods such as eggs, meat, dairy products, and whole grains as well as skin, horns and hair. It was not recognized as being derived of proteins until it was isolated from the horn of a cow in 1899. Human hair and skin contain approximately 10–14% cystine by mass. It was discovered in 1810 by William Hyde Wollaston.

Cystine is formed from the oxidation of two cysteine molecules, via the formation of a disulfide bond. In cell biology, cystine (found in proteins) can only exist in non-reductive (oxidative) organelles, such as the secretory pathway (ER, Golgi, lysosomes, vesicles and ECM). Under reductive conditions (in the cytoplasm, nucleus, etc.) cysteine is predominant. The disulfide link is readily reduced to give the corresponding thiol cysteine. Due to the facility of the thiol-disulfide exchange, the nutritional benefits and sources of cystine are identical to those for the more-common cysteine. Disulfide bonds cleave more rapidly at higher temperatures. Cystine also serves as a substrate for the cystine-glutamate antiporter. This transport system, which is highly specific for cystine and glutamate, increases the concentration of cystine inside the cell. In this system, the anionic form of cystine is transported in exchange for glutamate. Cystine is quickly reduced to cysteine.

Treatments can include Cysteine prodrugs, e.g. acetylcysteine, these induce release of glutamate into the extracellular space. Cysteine supplements are sometimes marketed as anti-aging products with claims of improved skin elasticity. Cysteine is more easily absorbed by the body than cystine, so most supplements contain cysteine rather than cystine. N-acetyl-cysteine (NAC) is better absorbed than other cysteine or cystine supplements.

More International ad National events happening 7 May

Mother Ocean Day
Beer Pong Day
Brunch for Lunch Day
Free Comic Book Day
Herb Day
Join Hands Day
National Babysitters Day
National Barrier Awareness Day
National Cosmopolitan Day
National Homebrew Day
National Roast Leg of Lamb Day
National Scrapbooking Day
National Tourism Day
Paste Up Day
Beaufort Wind Scale Day

Radio Day

Radio Day is celebrated in the Russian Federation and some Eastern European countries on 7 May. Radio Day commemorates the pioneering work of Russian physicist Alexander Stepanovich Popov who presented a paper on a self built wireless lightning detector on 7 May 1895.

Russian physicist Alexander Stepanovich Popov (sometimes spelled Popoff; Russian: Алекса́ндр Степа́нович Попо́в; was Born in Krasnoturinsk, Sverdlovsk Oblast in the Urals on March 16 [O.S. March 4] 1859. He was the son of a priest and became interested in natural sciences when he was a child. His father wanted Alexander to join the priesthood and sent him to the Seminary School at Yekaterinburg. However he developed an interest in science and mathematics and instead of going on to Theology School in 1877 he enrolled at St. Petersburg university where he studied physics. After graduation with honors in 1882, he stayed on as a laboratory assistant at the university. However the salary at the university was inadequate to support his family, and in 1883 he took a post as teacher and head of laboratory at the Russian Navy’s Torpedo School in Kronstadt on Kotlin Island.

Popov’s work as a teacher at a Russian naval school led him to explore high frequency electrical phenomena. Along with his teaching duties at the naval school Popov pursued related areas of research. Trying to solve a problem with the failure in the electrical wire insulation on steel ships (which turned out to be a problem with electrical resonance) led him to further explore oscillations of high frequency electrical current His interest in this area of study (including the new field of “Hertzian” or radio waves) was intensified by his trip in 1893 to the Chicago World’s Columbian Exposition in the United States where he was able to confer with other researchers in the field.

Popov also read an 1894 article about British physicist Oliver Lodge’s experiments related to the discovery of radio waves by German physicist Heinrich Hertz 6 years earlier. On 1 June 1894, after the death of Hertz, British physicist Oliver Lodge gave a memorial lecture on Hertz experiments. He set up a demonstration on the quasi optical nature of Hertzian waves (radio waves) and demonstrated their transmission at distances up to 50 meters. Lodge used a detector called a coherer, a glass tube containing metal filings between two electrodes. When received waves from an antenna were applied to the electrodes, the coherer became conductive allowing the current from a battery to pass through it, with the impulse being picked up by a mirror galvanometer. After receiving a signal, the metal filings in the coherer had to be reset by a manually operated vibrator or by the vibrations of a bell placed on the table nearby that rang every time a transmission was received. Popov designed a more sensitive radio wave receiver that could be used as a lightning detector, to warn of thunderstorms by detecting the electromagnetic pulses of lightning strikes using a coherer receiver.

On May 7, 1895, he presented a paper “On the Relation of Metallic Powders to Electric Oscillations”, which described his lightning detector, to the Russian Physical and Chemical Society in St. Petersburg which demonstrated the principal of the wireless lightning detector he had built that worked via using a coherer to detect radio noise from lightning strikes. This day is celebrated in the Russian Federation as Radio Day. In a March 24, 1896, demonstration, he used radio waves to transmit a message between different campus buildings in St. Petersburg. His work was based on that of another physicist – Oliver Lodge, and contemporaneous with the work of Guglielmo Marconi. Marconi had just registered a patent with the description of the device two months after first transmission of radio signals made by Popov.

In 1900 a radio station was established under Popov’s instructions on Hogland island (Suursaari) to provide two-way communication by wireless telegraphy between the Russian naval base and the crew of the battleship General-Admiral Apraksin which had run aground on Hogland island in the Gulf of Finland in November 1899. Although The crew of the Apraksin were not in immediate danger, the water in the Gulf began to freeze. However help did not arrive until January 1900 although By February 5 messages were being received reliably and the Apraksin was freed from the rocks by the icebreaker Yermak. Then Over 50 Finnish fishermen, who were stranded on a piece of drift ice in the Gulf of Finland, were also saved by the icebreaker Yermak following distress telegrams sent by wireless telegraphy. In 1901 Alexander Popov was appointed as professor at the Electrotechnical Institute, which now bears his name. In 1905 he was elected director of the institution.

Sadly In 1905 Popov became seriously ill and died of a brain hemorrhage on January 13, 1906. However his valuable contributions have been remembered: A minor planet, 3074 Popov, discovered by Soviet astronomer Lyudmila Zhuravlyova in 1979, is named after him. At ITU Telecom World 2011, Igor Shchyogolev, Minister of Telecom and Mass Communications of the Russian Federation alongside Hamadoun Touré, Secretary General of the ITU, inaugurated the “Alexander Stepanovich Popov” conference room at ITU’s headquarters in Geneva.

Robert Browning

English poet and playwright Robert Browning was born 7 May 1812 in Walworth in the parish of Camberwell, Surrey. Browning’s early career began promisingly, but was not a success. The long poem Pauline brought him to the attention of Dante Gabriel Rossetti, and was followed by Paracelsus, which was praised by Wordsworth and Dickens, but in 1840 the difficult Sordello, which was seen as wilfully obscure, brought his poetry into disrepute. His reputation took more than a decade to recover, during which time he moved away from the Shelleyan forms of his early period and developed a more personal style.

In 1846 Browning married the older poet Elizabeth Barrett, who at the time was considerably better known than himself. So started one of history’s most famous literary marriages. They went to live in Italy, a country he called “my university”, and which features frequently in his work. His mastery of the dramatic monologue made him one of the foremost Victorian poets. His poems are known for their irony, characterization, dark humour, social commentary, historical settings, and challenging vocabulary and syntax.

By the time of her death in 1861, he had published the crucial collection Men and Women. The collection Dramatis Personae and the book-length epic poem The Ring and the Book followed, and made him a leading British poet. He continued to write prolifically, but his reputation today rests largely on the poetry he wrote in this middle period. When Browning died in 1889, he was regarded as a sage and philosopher-poet who through his writing had made contributions to Victorian social and political discourse – as in the poem Caliban upon Setebos, which some critics have seen as a comment on the theory of evolution, which had recently been put forward by Darwin and others. Unusually for a poet, societies for the study of his work were founded while he was still alive. Such Browning Societies remained common in Britain and the United States until the early 20th century.

Some of Browning’s most ambitious poems, include The Ring and the Book and have included such eminent writers as Henry James, Oscar Wilde, George Bernard Shaw, G. K. Chesterton, Ezra Pound, Jorge Luis Borges, and Vladimir Nabokov. Among living writers, Stephen King’s The Dark Tower series and A.S. Byatt’s Possession refer directly to Browning’s work. Some of Browning’s best poems include the monologues Childe Roland to the Dark Tower Came, Fra Lippo Lippi, Andrea Del Sarto, and My Last Duchess. His most popular poems include Porphyria’s Lover, How They Brought the Good News from Ghent to Aix, the diptych Meeting at Night, the patriotic Home Thoughts from Abroad, and the children’s poem The Pied Piper of Hamelin.

Robert Browning sadly died on 12 December 1889 however his poetry remains popular and His dinner-party recital of How They Brought The Good News which was recorded on an Edison wax cylinder, is believed to be the oldest surviving recording made in the United Kingdom by a notable person.

Bill kreutzman (Grateful dead)

Bill Kreutzman drummer with American rock band the Grateful Dead was born 7 May 1946. The Grateful Dead were formed in 1965 in the San Francisco Bay Area. The band were known for their unique and eclectic style, which fused elements of rock, folk, bluegrass, blues, reggae, country, improvisational jazz, psychedelia, and space rock, and for live performances of long musical improvisation. “The founding members of the Grateful Dead were Jerry Garcia (guitar, vocals), Bob Weir (guitar, vocals), Ron “Pigpen” McKernan (keyboards, harmonica, vocals), Phil Lesh (bass, vocals), and Bill Kreutzmann (drums). Lesh was the last member to join the Warlocks before they became the Grateful Dead; he replaced Dana Morgan Jr., who had played bass for a few gigs.

With the exception of McKernan, who died in 1973, the core of the band stayed together for its entire 30-year history. Phil Lesh and Jerry Garcia were brought together by Gert Chiarito in 1964 to perform on The Midnight Special. The Grateful Dead began their career as the Warlocks, a group formed in early 1965 from the remnants of a jug band called Mother McCree’s Uptown Jug Champions, although The band changed its name after finding out that another band of the same name had signed a recording contract. The name “Grateful Dead” was chosen from a dictionary, The definition being that there was “the soul of a dead person, or his angel, showing gratitude to someone who, as an act of charity, arranged their burial.”One of the group’s earliest major performances in 1967 was at the Avalon Ballroom by the San Francisco Hare Krishna temple. The Grateful Dead performed at the event along with the Hare Krishna founder Bhaktivedanta Swami, poet Allen Ginsberg, bands Moby Grape and Big Brother and the Holding Company with Janis Joplin, donating proceeds to the Krishna temple. The band’s first LP, The Grateful Dead, was released in 1967. 1970 included tour dates in New Orleans, Louisiana, where the band performed at The Warehouse for two nights.

Mickey Hart quit the Grateful Dead in February 1971, leaving Kreutzmann once again as the sole percussionist. Hart rejoined the Grateful Dead for good in October 1974. Tom “TC” Constanten was added as a second keyboardist from 1968 to 1970, while Pigpen also played various percussion instruments and sang. Following the Grateful Dead’s “Europe ’72″ tour, Pigpen’s health had deteriorated to the point that he could no longer tour with the band. His final concert appearance was June 17, 1972 at the Hollywood Bowl, in Los Angeles and he died in March, 1973 of complications from alcohol abuse. The Grateful Dead formed their own record group, Grateful Dead Records & Later that year, they released their next studio album, the jazz influenced Wake of the Flood. It became their biggest commercial success thus far.During the late 1970s the band went back to the studio, and the next year released another album, Grateful Dead from the Mars Hotel. Not long after that album’s release however, the Grateful Dead decided to take a hiatus from live touring so that its members could focus on their solo careers. This hiatus was short lived, though, as they resumed touring in 1976, and released another album Terrapin Station in 1977.

During the 1980s the bands sound transformed. Sadly though Garcia’s health began to decline. His drug habits caused him to lose his liveliness on stage. After kicking his drug habit in 1985, he slipped into a diabetic coma for several days in July 1986. After he recovered, the band released In the Dark in 1987, which resulted as their best selling studio album release, and also produced their only top-10 chart single, Touch of Grey. Inspired by Garcia’s improved health and a successful album, the band’s energy and chemistry peaked in the late 1980s and 1990. Performances were vigorous and as a result, every show exceeded its maximum audience capacity. The band’s “high time” came to a sudden halt when Mydland died after the summer tour in 1990. So Vince Welnick, joined on keyboards and vocals and Bruce Hornsby joined the band as the pianist and vocals on September 15, 1990.

Their Greteful Dead touched on ground that most other groups don’t even know exists.” These various influences were distilled into a diverse and psychedelic whole that made the Grateful Dead “the pioneering Godfathers of the jam band world.” They were ranked 57th in the issue The Greatest Artists of all Time by Rolling Stone magazine. They were inducted into the Rock and Roll Hall of Fame in 1994 and their Barton Hall Concert at Cornell University was added to the Library of Congress’s National Recording Registry. Bill Kreutzmann also released a memoir February 2020. The fans of the Grateful Dead, some of whom followed the band from concert to concert for years, are known as “Deadheads” and are known for their dedication to the band’s music. From 2003 to 2009 former members of the Grateful Dead, along with other musicians, toured as The Dead and The Other Ones. There are many contemporary incarnations of the Dead, with the most prominent touring acts being Furthur and Phil Lesh & Friends.